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J. Venom. Anim. Toxins.
Vol.2, No.2, p.156-161, 1996.
Short communication - ISSN 0104-7930.
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J. Venom. Anim. Toxins. Vol.2, No.2, p.156-161, 1996. Short communication - ISSN 0104-7930. |
MEASUREMENT OF BRADYKININ, PROTEIN, Na+, Cl-, K+, AND Zn++ CONCENTRATIONS IN RAT URINE AFTER INTRAPERITONEAL INJECTION OF Tityus serrulatus VENOM
L. A. F. FERREIRA(1), M. BERGAMASCO(1), L. ANGNES(2)
1 Laboratory of Biochemistry and Biophysics, Butantan Institute, State of São Paulo, Brazil; 2 Department of Chemistry, University of São Paulo, State of São Paulo, Brazil.
ABSTRACT. Experiments were carried out in vivo by injecting Tityus serrulatus crude venom in rats followed by biological assays on the isolated guinea-pig ileum, to show the effects of scorpion venom on kallikrein-kinin system. Our results showed effects such as significant decrease of total kinin rate and a decrease of Zn++, Na+, Cl- and K+ ions in rat urine 24 and 48 hours after the injection of Tityus serrulatus crude venom.
KEY WORDS: Bradykinin, protein, ions,Tityus serrulatus.
CORRESPONDENCE TO:
L. A. F. FERREIRA - Laboratório de Bioquímica e Biofísica, Instituto Butantan, Av.Vital Brasil, 1500, CEP 05503-900, São Paulo, Brasil.