Sea-animals toxins as useful targets for molecular modeling and drug-design

MAIGRET, B.(1)

(1)Laboratory of Theoretical Chemistry, UMR CNRS/UHP 756, Université Henri Poincaré, France.

Sea animal species are, with those coming from tropical rain forests, the largest reservoir for natural products finding. Considering the impact of such natural products in drug discovery for a large variety of diseases, attention will be presented on the use of sea animals venom for drug design. Several examples coming from sea anemone toxins will be used in this presentation, highlighting the necessary combination of multidisciplinary approaches. Computer modelling investigations will be described complementing successfully structural and biochemical experiments.

CORRESPONDENCE TO:

MAIGRET, B. Laboratory of Theoretical Chemistry, UMR CNRS/UHP 756, Université Henri Poincaré, France. E.mail: maigret@unb.br