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J. Venom. Anim. Toxins incl. Trop. Dis. Vol.9, No.2, p.530, 2003. Poster - ISSN 1678-9199. |
LOCAL TREATMENT OF EXPERIMENTAL ENVENOMING BY Bothrops alternatus IN DOGS WITH THE AQUEOUS EXTRACT OF Kalanchoe brasiliensis
SILVA JUNIOR, P.G.P.(1), MELO, M.M.(1), CARDOSO, R.R.(1), FERREIRA, K.M.(1), FONSECA, F.V.(1), LAGO, L.A.(1), HABERMEHL, G.G.(2)
(1)Departamento de Clínica e Cirurgia, Escola de Veterinária, UFMG, Brasil, (2)Chemisches Institut, Tierärztliche Hochschule, Hannover, Germany
The bothropic venom acts locally causing edema, hemorrhagic halo and necrosis around the affected area. The traditional treatment with anti-serum is only effective to antagonize the systemic effects, but it does not neutralize local lesions. Bothropic envenoming may have severe consequences such as loss of the limb due to necrosis. Auxiliary treatments must be developed in order to antagonize these local effects. The aim of this study was to verify the effectiveness of the aqueous extract of Kalanchoe brasiliensis (100%) compared to placebo (saline). Desiccated venom of Bothrops alternatus (0.3mg/kg) was diluted in saline and injected IM in ten dogs. These dogs were divided into two groups: Group I was treated with Saline and Group II received topic treatment with Kalanchoe brasiliensis(100%). These treatments began 30’ after venom inoculation, and were repeated at 3, 6, 12, 24 hours after inoculation. After 24 hours the treatment was repeated twice a day for 14 days. The lesions were evaluated once a day by measuring the skin thickness (edema) with a pachymeter, the hemorrhagic halo with a special ruler and by observing the appearance of ulcers in dermis (necrosis). Immediately after the inoculation, local edema was observed and all dogs presented signs of pain. Decrease of edema and the hemorrhagic halo was observed in dogs treated with Kalanchoe brasiliensis, this group had a better recovery when compared to the Control group (Saline). Our results support the notion that the aqueous extract of Kalanchoe brasiliensis is effective in antagonizing the local effects against Bothrops alternatus venom.
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