Received: October 21, 2002.  Accepted: November 11, 2002.  Published online: June 5, 2004.

EXPERIMENTAL USE OF FIBRIN GLUE DERIVED FROM SNAKE VENOM IN NON-PREGNANT CANINE UTERUS

MORAES, J.R.E.1; CORREIA, P.H.A.1; CAMPLESI, A.C.1; MORAES, F.R.1

1 Departamento de Patologia Veterinária, Faculdade de Ciências Agrárias e Veterinárias, Universidade Estadual Paulista (UNESP), Jaboticabal, São Paulo, Brasil.

ABSTRACT. This study evaluated the use of fibrin glue derived from snake venom in the healing process after canine hysterorrhaphy. Three groups of four animals were submitted to uterine hysterotomy followed by wound closure. In Group 1, double-layer suture was used, the first with Schimieden pattern, the second with Cushing pattern; in Group 2, only fibrin glue; and in Group 3, the same as for Group 1 but with fibrin glue as suture reinforcement. Results indicated that fibrin glue produced less inflammation in the exudative phase, and exacerbated deposition of connective tissue and angiogenesis in the proliferative and maturation phases of the healing process, favoring its evolution.

KEY WORDS: healing, fibrin glue, uterus, surgical adhesives, wound closure.

CORRESPONDENCE TO:

J. R. E. de Moraes – Laboratório de Patologia Experimental e Comparada, Departamento de Patologia Veterinária, Universidade Estadual Paulista (UNESP), Campus de Jaboticabal, Via de Acesso Prof. Dr. Paulo Donato Castellane, s/n, 14884-900, Jaboticabal, São Paulo, Brasil.