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Poster 76. Congresso da Sociedade Brasileira de Toxinologia, 8., Symposium of the Pan American Section of the International Society on Toxinology, 8., 2004, Angra dos Reis, Brasil. Abstracts... J. Venom. Anim. Toxins incl.Trop. Dis., 2004, 10, 3, p.435. |
Study Of The Action OfExtracts From Erythrina mulunguAgainst Venom Poisoning Of Bothrops jararaca, Tityus serrulatusAnd Phoneutria nigriventer.
1Simokomaki, k; 1Barreto, S. A., 1Chaguri, L. C. G. & 1Lebrun, I.
1 Biochemistry and Biophysic Laboratory – Butantan Institute, São Paulo - Brazil
In Brazil, the extracts or infusions of fresh plants are used to heal common infections, mainly in far places of the great urban centers and among the indigenous people. The popular knowledge on medicinal plants contributes to the benefit of the human health. Some of these plants are used against bites of poisonous animals as the snakes, that can take the individual to death. Although the snake poisoning is now treated with the specific antiserum, it is observed that some plants used by the population against poison of snakes exhibit some partial effect against the venom among them "Teiú " herb, the Calathea rotundifolia and the Anonna mutricata, besides the Erythrina mulungu. In the present work extracts obtained from the seeds of the Erythrina mulungu were tested in the capacity to neutralize the effects provoked by Bothrops jararaca's venom, Tityus serrulatus and Phoneutria nigriventer. Preliminary tests in mice pretreated with the organic extract of the seed of the Erytrina mulungu and with poison of Bothrops jararaca, Tityus serrulatus and Phoneutria nigriventer, demonstrated a decrease in the lethality up to 80%. Specific with the Tityus serrulatus venom, being less effective with Bothrops jararaca venom.
Acknowledgements to Mr. Sebastião Nascimento de Jesus for the collection of the material in the area of Ibitita and Irecê, State of Bahia.
Correspondence to: kimiesimo@butantan.gov.br