Poster 164.  Congresso da Sociedade Brasileira de Toxinologia, 8., Symposium of the Pan American Section of the International Society on Toxinology, 8., 2004, Angra dos Reis, Brasil.  Abstracts...  J. Venom. Anim. Toxins incl.Trop. Dis., 2004, 10, 3, p.523.

 

 

The differences between wild and captive Crotalus durissus colLilineatus venom in antinociceptive and edema inducing activities

 

1Moreira, K.G., 2Brito, V.L.M., 3Varela, G.M.F., 3Amora, D.N., 4Lima Jr, R.C.P., 3Nogueira, R.M.D., 1Silva Jr., N.J.

 

1 Mestrado Ciências Ambientais e Saúde, Universidade Católica de Goiás; 2 Centro de Estudos e Pesquisas Biológicas, Universidade Católica de Goiás; 3 Laboratório de Farmacologia da Dor (LAFAD), Depto.Fisiologia e Farmacologia, UFC,Ceará; 4 Laboratório de Produtos Naturais (LPN), Depto.Fisiologia e Farmacologia, UFC,Ceará.

 

The biological activity of the venom of the snake Crotalusdurissus varies drastically according to the geographic origin of the specimens. The snakes of Central America, for example, present high proteolitic, hemorrhagic and edema inducing while the species of South America present high miotoxic activity with discreate local symptoms. However, in some clinical cases there were reports of edema and even abcesses in the site of the bite. The objective of this study was to evaluate the differences in the antinociceptive and edematogenic activities of the venom of snake C.d.collilineatuswith specimens born in captivity (CdcNC) and recently arrived from natural habitats (CdcN). The antinociceptive activity was evaluated using the acetic acid writhing test (0,6%, 0,1mL/10g, i.p.), hot plate (51±1ºC) and tail flick (52±1ºC). The edematogenic activity was determined using rat paw edema. The venoms CdcNC and CdcN did not present significant statistical differences in the antinociceptive activity while in the edematogenic activity the venoms presented differences, where the CdcNC venom was responsible for a stronger action than CdcN venom in all timing tested. The edema development rapidly reached its maximum intensity in 30 minutes. Based on the this preliminary findings we can suggest that the differences in the edematogenic activity may be related to venom composition due to different habitats and behaviour (natural vs. laboratory) or other reasons not yet described in the toxinology literature.

 

Correspondence to: tuve@bol.com.br