RED BLOOD CELLS ALLOIMMUNIZATION IN ONCOLOGY PATIENTS IN PORTO VELHO, RONDONIA – BRAZIL

ROSSI-FERREIRA R.(1), GOLIM M. A.(1), HURTADO C. N.(2), NEGRAES R.(2), PAIVA A. J. F.(2), GALINDO L. D. P.(2), DEFFUNE E.(1)

(1)Botucatu Blood Center, São Paulo, Brazil, (2)Rondonia Hematology Foundation, Rondonia - Brazil

Alloimmunization to erythrocyte antigens is a well-characterized complication in heavily transfused like oncology patients. The aim of this study was determine the alloimmunization occurrence in oncology patients in Rondonia State, region of known flow migratory with large red blood cells (RBC) antigens diversity. Eighty-seven samples was collected and distributed in the following groups: oncology patients without transfusion (n=19); healthful voluntary that had never received transfusion (n=26); oncology patients that had received transfusion (n=19) and voluntary participants that already had made transfusion use (n=23), being the same ones submitted to the irregular antibody screening and identification if positive. The participants were submitted to a questionnaire. It was observed a fewer antibody presence on oncology participants (5%) that had received transfusion comparing non-oncology participants (16%) that also had received transfusion. The oncology patients, despite to have a great number of transfusions and a short pass time between the transfusions and the examination had a fewer antibody presence, probably to immunity fall due base illness and treatment.

KEY WORDS: alloimunization, oncology, erythrocyte antigens

CORRESPONDENCE TO:

Rosana Rossi Ferreira. Hemocentro, Distrito Rubião Júnior, s/nº - campus da UNESP, Botucatu, SP, CEP: 18.618-000. Email: rossi@fc.unesp.br