EFFECTS OF POLYPHENOLIC COMPOUNDS ON THE STRUCTURE AND FUNCTION OF TOXINS.

TOYAMA, M.H. (1)

(1)UNESP, CELP, São Vicente

Polyphenolic compounds are wide spread substance in the nature, mainly found in the vegetable.  These compounds are extensively used for production of relevant antioxidant compound that in some case they are used commercially as therapeutic compound.   The main character of these compound flavonoids and its derivates is its strong antioxidant properties.   Recently we investigate the effect of morin on the structure and function of PLA2 and we observed that morin induced significative modification of secondary structure of the protein but did not abolish its pharmacological action.  In this presentation we present the effect of other flavonoids on the function and structure of PLA2 and other toxins.  The main conclusion is the possibility of these compounds helps us to understand more of some structural or pharmacological actions of PLA2 and other toxins

KEY WORDS: PLA2, toxins, snake venom, flavonoids.

FINANCIAL SUPPORT: FAPESP, CNPq.