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J. Venom. Anim. Toxins incl. Trop. Dis.

V.20, 2014.

Original paper - ISSN 1678-9199.

 

Preliminary assessment of Hedychium coronarium essential oil on fibrinogenolytic and coagulant activity induced by Bothrops and Lachesis snake venoms

 
Cíntia A S F Miranda 1 , Maria G Cardoso1 3, Mariana E Mansanares2, Marcos S Gomes1, Silvana Marcussi1

1Department of Chemistry, Federal University of Lavras (UFLA), Lavras, Minas Gerais State, Brazil

2Department of Biology, Federal University of Lavras (UFLA), Lavras, Minas Gerais State, Brazil

3Laboratório de Química Orgânica, Departamento de Química, Universidade Federal de Lavras, Caixa postal 3037, CEP 37200-000 Lavras, MG, Brasil

ABSTRACT

Background

The search for new inhibitors of snake venom toxins is essential to complement or even replace traditional antivenom therapy, especially in relation to compounds that neutralize the local effects of envenomations. Besides their possible use as alternative to traditional antivenom therapy, some plant species possess bioactive secondary metabolites including essential oils, which can be extracted from weeds that are considered substantial problems for agriculture, such as Hedychium coronarium.

 

ACKNOWLEDGMENTS

The authors would like to thank the National Council for Scientific and Technological Development (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES), and the State of Minas Gerais Research Foundation (FAPEMIG) for financial support and scholarships.