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J. Venom. Anim. Toxins incl. Trop. Dis.

V.20, 2014.

Review article - ISSN 1678-9199.

 

Septic arthritis: immunopathogenesis, experimental models and therapy

 
Priscila Maria Colavite, Alexandrina Sartori*

 

Departamento de Microbiologia e Imunologia, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Distrito de Rubião Júnior, s/n, Botucatu, São Paulo State, Brazil

 

ABSTRACT

Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included.

 

Key words: Septic arthritis; Staphylococcus aureus; Mice

 

Received: January 31, 2014; Revised: April 22, 2014; Accepted: May 6, 2014

 

Corresponding author: Alexandrina Sartori sartori@ibb.unesp.br

 

Authors’ contributions

PMC and AS equally contributed to conceiving and writing this review. Both authors read and approved the final manuscript.

 

Competing interests

The authors declare that there are no competing interests.