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Animal toxins: exploring novel bioactive compounds from toads, snakes and scorpions
Collection

Animal toxins: exploring novel bioactive compounds from toads, snakes and scorpions

Given its huge biodiversity, which includes a great amount of venomous and poisonous animal species, Brazil is well-known for its toxinological research. In this special collection published in Journal of Venomous Animals and Toxins including Tropical Diseases, we present a series of studies which have been carried out by a high-profile group of Brazilian researchers from the Research Support Center on Animal Toxins (NAP-TOXAN-USP) at University of São Paulo in Ribeirão Preto, and have been funded by the São Paulo Research Foundation (Fapesp).

These studies describe new compounds from toad poison and snake and scorpion venoms using different approaches for their isolation and structural and functional characterization, aiming at the discovery of new candidate molecules. We are delighted to publish them as a special collection and believe it will be of interest for all involved not only with Toxinology but also with drug discovery and biotechnology development.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Editor declares no competing interests.

Research  

Partial purification and functional characterization of Ts19 Frag-I, a novel toxin from Tityus serrulatus scorpion venom

Priscila C. Lima, Karla C. F. Bordon, Manuela B. Pucca, Felipe A. Cerni, Karina F. Zoccal, Lucia H. Faccioli and Eliane C. Arantes 
Research  

In vitro activity of phospholipase A2 and of peptides from Crotalus durissus terrificus venom against amastigote and promastigote forms of Leishmania (L.) infantum chagasi

Gustavo A. C. Barros, Andreia V. Pereira, Luciana C. Barros, Airton Lourenço Jr, Sueli A. Calvi, Lucilene D. Santos, Benedito Barraviera and Rui Seabra Ferreira Jr.
Research   

Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes

Andrea Casella-Martins, Lorena R. Ayres, Sandra M. Burin, Fabiana R. Morais, Juliana C. Pereira, Lucia H. Faccioli, Suely V. Sampaio, Eliane C. Arantes, Fabiola A. Castro and Luciana S. Pereira-Crott 
Research   

Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines

Cássio Prinholato da Silva, Tássia R. Costa, Raquel M. Alves Paiva, Adélia C. O. Cintra, Danilo L. Menaldo, Lusânia M. Greggi Antunes and Suely V. Sampaio
Review   

Snake venom galactoside-binding lectins: a structural and functional overview

Marco A. Sartim and Suely V. Sampaio
Short report   

First serine protease inhibitor isolated from Rhinella schneideri poison

Priscila Y. T. Shibao, Fernando A. P. Anjolette, Norberto P. Lopes and Eliane C. Arantes 
Research   

Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways

Lorena Rocha Ayres, Alex dos Reis Récio, Sandra Mara Burin, Juliana Campos Pereira, Andrea Casella Martins, Suely Vilela Sampaio, Fabíola Attié de Castro and Luciana Simon Pereira-Crott 
Research   

Purification procedure for the isolation of a P-I metalloprotease and an acidic phospholipase A2 from Bothrops atrox snake venom

Danilo L. Menaldo, Anna L. Jacob-Ferreira, Carolina P. Bernardes, Adélia C. O. Cintra and Suely V. Sampaio
Research   

Bordonein-L, a new L-amino acid oxidase from Crotalus durissus terrificus snake venom: isolation, preliminary characterization and enzyme stability

Karla C. F. Bordon, Gisele A. Wiezel, Hamilton Cabral and Eliane C. Arantes
Research   

Biological characterization of compounds from Rhinella schneideri poison that act on the complement system

Fernando A. P. Anjolette, Flávia P. Leite, Karla C. F. Bordon, Ana Elisa C. S. Azzolini, Juliana C. Pereira, Luciana S. Pereira-Crott and Eliane C. Arantes
Review   

Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva

Francielle A. Cordeiro, Fernanda G. Amorim, Fernando A. P. Anjolette and Eliane C. Arantes