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Highlights in arthropod venoms: potential applications in medicine and biotechnology
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Highlights in arthropod venoms: potential applications in medicine and biotechnology

Edited by: Maria Elena de Lima, Yong-Hua Ji and Maria Maria Stankiewicz

With over 800,000 species, many of them venomous, the phylum Arthropod is still underexplored from a toxinological perspective. Taken together, the venoms of these animals may contain millions of potentially active molecules and some of them have already been key in the investigation of receptors, ion channels and other cellular structures and functions, offering new perspectives for the development of drugs, treatments and biotechnologies.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

Review 

Arthropod venom hyaluronidases: biochemical properties and potential applications in medicine and biotechnology

Karla C. F. Bordon, Gisele A. Wiezel, Fernanda G. Amorim and Eliane C. Arantes
Research 

Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain

Yi-Jun Feng, Qi Feng, Jie Tao, Rong Zhao and Yong-Hua Ji
Research 

Exposure to 50 Hz electromagnetic field changes the efficiency of the scorpion alpha toxin

Milena Jankowska, Agnieszka Pawlowska-Mainville, Maria Stankiewicz, Justyna Rogalska and Joanna Wyszkowska
Review 

Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders

Victoria Monge-Fuentes, Flávia Maria Medeiros Gomes, Gabriel Avohay Alves Campos, Juliana de Castro Silva, Andréia Mayer Biolchi, Lilian Carneiro dos Anjos, Jacqueline Coimbra Gonçalves, Kamila Soares Lopes and Márcia Renata Mortari
Review 

A checklist of the scorpions of Ecuador (Arachnida: Scorpiones), with notes on the distribution and medical significance of some species

Gabriel Brito and Adolfo Borges
Review 

The history of venomous spider identification, venom extraction methods and antivenom production: a long journey at the Butantan Institute, São Paulo, Brazil

Sylvia M. Lucas
Research 

A comparison between the recombinant expression and chemical synthesis of a short cysteine-rich insecticidal spider peptide

Herlinda Clement, Vianey Flores, Elia Diego-Garcia, Ligia Corrales-Garcia, Elba Villegas and Gerardo Corzo
Review 

The unfulfilled promises of scorpion insectotoxins

Ernesto Ortiz and Lourival D. Possani
Research 

Pharmacological characterization of venoms from three theraphosid spiders: Poecilotheria regalis, Ceratogyrus darlingi and Brachypelma epicureanum

Alejandro García-Arredondo, Luis Rodríguez-Rios, Luis Fernando Díaz-Peña and Ricardo Vega-Ángeles
Review 

What do we know about some of the most conspicuous scorpion species of the genus Tityus? A historical approach

Wilson R. Lourenço